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Although subcutaneous injections of svL4 did not reduce epidermal thickness, an increased density of dermal collagen was noted as thicker bundles with more intense eosin staining (not shown) svL4 reduced disrupted areas after induction with HDM and SEB To determine whether svL4 is effective against irritants other than LPS, for example, serve as a general treatment, eczema was also induced with a combination of HDM extract and SEB, which are commonly encountered allergens (Kawakami et al., 2007)

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